Corpo Docente

Curriculum Vitae

Veterinary Physician graduated from the Londrina State University, specialized in Clinics and Surgery of Small Animals by the Faculty of Veterinary Medicine and Animal Science of USP, where she got a Master’s and Doctorate in Applied Experimental Epidemiology at Zoonosis. Productivity Fellow 2, belongs to the CNPq research groups in Clinical and Infectious Diseases (UNIP) and Biology of Cell Differentiation and Transformation: Modulation by Endogenous and Exogenous factors. Her research theme covers opportunistic and emerging protozoa, involving epidemiological, pathogenic and immunological aspects, particularly in the study of microsporidiosis in mammals, with emphasis on the parasite-host relationship. Since the Postdoctoral stage with the project "The role of B-1 cells in experimental infection by E. cuniculi in mice", a new research theme involving innate immunity, B-1 cells and cell death in Microsporidioses was introduced.

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Research Lines and Groups

• Clininfec - Clínica e Doenças Infecciosas Veterinárias
• Biologia da diferenciação e transformação celulares: modulação por fatores endógenos e exógenos
• Neuropsicofarmacologia Experimental e Ambiental
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Seminários de Projetos
• Epidemiologia Aplicada ao Ambiente e à Saúde
• Seminários da Semana Científica

Highlighted publications

Spadacci-Morena DD et al. 2021. Encephalitozoon cuniculi takes advantage of efferocytosis to evade the immune response. PLoS One, 16:e0247658. DOI: https://doi.org/10.1371/journal.pone.0247658

Moura MLC et al. 2019. Cyclophosphamide Treatment Mimics Sub-Lethal Infections With Encephalitozoon intestinalis in Immunocompromised Individuals. Front Microbiol, 10:2205-2205. DOI: https://doi.org/10.3389/fmicb.2019.02205

Pereira A et al. 2019. B-1 cell-mediated modulation of M1 macrophage profile can ameliorate microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PLoS Negl Trop Dis, 13: e0007674. DOI: https://doi.org/10.1371/journal.pntd.0007674

Langanke dos Santos D et al. 2018. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbes infect, 20:196-204. DOI: https://doi.org/10.1016/j.micinf.2017.11.004

Dos Santos MF. 2018. Morphodifferentiation of Gené’s organ in engorged Amblyomma sculptum Berlese, 1888 female ticks (Acari: Ixodidae). Ticks Tick Borne Dis, 9:519-525. DOI: https://doi.org/10.1016/j.ttbdis.2018.01.004

Curriculum Vitae

Pharmacist, Master’s and Ph.D. by USP-SP, Post-Doctorate in Toxicology, by Universidade Paulista. Responsible for the Center for Research in Biodiversity-UNIP. CNPq Productivity Fellow 2. Member of the Ethics Committee on the Use of Animals. She works in Pharmacognosy, Pharmacology, and Toxicology of Medicinal Plants and Microbiology, with the themes Evaluation of Antitumor, Antimicrobial, Antioxidant, Toxicity and Behavioral Changes of plant extracts and essential oils, with interest focused on Veterinary and Human Medicine. She is one of the leading researchers of the Rio Negro Project. Leader of the Research Group Biological, Pharmacological and Toxicological Activities of Natural Products, researcher of the Neuropsychopharmacology Experimental and Environmental, Therapeutic and Curative Schemes Proposed and Recommended in the Treatment of Oral Diseases Group and Briotech Group, which studies Antarctic bryophytes.

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Research Lines and Groups

• Atividades Biológicas, Farmacológicas e Toxicológicas de Produtos Naturais
• Terapêutica Medicamentosa Aplicada às Ciências da Saúde
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Produtos Naturais em Ciências da Saúde
• Bioética e Metodologia Científica
• Tópicos Especiais Aplicados à Educação
• Seminários de Projetos
• Seminários da Semana Científica

Highlighted publications

Frias HV et al. 2021. Vertical exposition to Luffa operculata extract deregulates behavior and hypothalamus neurotransmitters in juvenile rats. J. Ethnopharmacology, 264:113265. DOI: https://doi.org/10.1016/j.jep.2020.113265

Martins ER et al. 2019. Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach. PLoSOne. 14(11):e0224406. DOI: https://doi.org/10.1371/journal.pone.0224406

Martins ER et al. 2019. Interference of Seasonal Variation on the Antimicrobial and Cytotoxic Activities of the Essential Oils from the Leaves of Iryanthera polyneura in the Amazon Rain Forest. Chemistry & Biodiversity. 16(10):e1900374. DOI: https://doi.org/10.1002/cbdv.201900374

Alves CS et al. 2018. Luffa Operculata Fruit Aqueous Extract Induces Motor Impairments, Anxiety-Like Behavior, And Testis Damage In Rats. Journal of Ethnopharmacology, 222:52-60. DOI: https://doi.org/10.1016/j.jep.2018.04.044

Suffredini IB et al. 2017. Mice Behavioral Phenotype Changes after Administration of Anani (Symphonia globulifera, Clusiaceae), an Alternative Latin American and African Medicine. Pharmacognosy Magazine, 13:617-626. DOI: https://doi.org/10.4103/pm.pm_168_17

Curriculum Vitae

Veterinarian by University of Marília (UNIMAR) (1992 - 1997). Master's degree in Animal Science by Paulista State University (UNESP), Ilha Solteira (1997 - 2000) and PhD in Experimental Epidemiology Applied to Zoonoses by Faculty of Veterinary Medicine and Animal Science of the University of São Paulo (FMVZ/USP) (2001 - 2005). Post doctor degree by Faculty of Veterinary Medicine and Animal Science at the University of São Paulo (2008 - 2013) and at the Veterinary Diagnostic and Production Animal Medicine at Iowa State University (2019 - 2020). Coordinated two FAPESP projects - Young Researcher (2009 - 2013) and a regular one (2016 - 2018). Experience in Genetics, with emphasis on Molecular Genetics of Viruses. Reviewer of national and international scientific journals. Works mainly on the following topics: microbiology (emphasis on bacteria and viruses); Vaccine development and laboratory diagnosis for infectious diseases. Since 2016, has been participated in vaccine development projects for swine at Iowa State University.

Médico Veterinario graduado en la Universidad de Marília (UNIMAR) (1992 - 1997). Maestría en Ciencia Animal de la UNESP, Universidade Estadual Paulista, Campus de Ilha Solteira (1997 - 2000) y Doctorado en Epidemiología Experimental Aplicada a las Zoonosis de la Facultad de Medicina Veterinaria y Ciencia Animal de la Universidad de São Paulo (FMVZ/USP) (2001 - 2005). Realizó estudios de Postdoctorado en la Facultad de Medicina Veterinaria y Ciencia Animal de la Universidad de São Paulo (2008 - 2013) y en Medicina Veterinaria de Diagnóstico y Producción Animal en la Universidad Estatal de Iowa (2019 - 2020). Coordinó el proyecto Joven Investigador (2009 - 2013) y el proyecto regular FAPESP (2016 - 2018). Experiencia en Genética, con énfasis en Genética Molecular de Virus. Revisor de revistas científicas nacionales e internacionales. Trabaja principalmente en los siguientes temas: microbiología (énfasis en bacterias y virus); desarrollo de vacunas y diagnóstico de laboratorio para enfermedades infecciosas. Desde 2016, ha participado en proyectos de desarrollo de vacunas porcinas en la Universidad Estatal de Iowa.

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Research lines and Groups

Clininfec - Clínica e Doenças Infecciosas Veterinárias

Disciplines

Epidemiologia Aplicada ao Ambiente e à Saúde (colaboradora)
Epigenética básica I (colaboradora)
Emergência e reemergencia das doenças infecciosas no mundo globalizado (responsável)

Highlighted publications

KARUPPANNAN, ANBU K.; DE CASTRO, ALESSANDRA MARNIE M. G.; OPRIESSNIG, TANJA. Recent Advances in Veterinary Diagnostic Virology. Advanced Techniques in Diagnostic Microbiology. 3ed.: Springer International Publishing, 2018, p. 317-344. DOI: 10.1007/978-3-319-95111-9_14
CORTEZ, A.; METORIMA, C.S.; MIYAGI, S.A.T.; SOUSA, A.O.; PEYSER, A.V.; CASTRO, A.M.M.G.; BALDISSERI JR, F.A.; SOUZA FILHO, A.F.; BRANDÃO, P.E.; HEINEMANN, M.B. High genetic diversity of hepatitis E virus in swine in São Paulo State, Brazil. ARQUIVO BRASILEIRO DE MEDICINA VETERINÁRIA E ZOOTECNIA (ONLINE), v. 73, p. 1237-1242, 2021. https://doi.org/10.1590/1678-4162-12203
OPRIESSNIG, TANJA; KARUPPANNAN, ANBU K.; CASTRO, ALESSANDRA M.M.G.; XIAO, CHAO-TING. Porcine circoviruses: current status, knowledge gaps and challenges. VIRUS RESEARCH, v. 286, p. 198044, 2020. https://doi.org/10.1016/j.virusres.2020.198044
OPRIESSNIG, TANJA; CASTRO, ALESSANDRA M.M.G.; KARUPPANAN, ANBU K.; GAUGER, PHILLIP C.; HALBUR, PATRICK G.; MATZINGER, SHANNON R.; MENG, XIANG-JIN. A Porcine circovirus type 2b (PCV2b)-based experimental vaccine is effective in the PCV2b-Mycoplasma hyopneumoniae coinfection pig model. VACCINE, v. 37, p. 6688-6695, 2019. https://doi.org/10.1016/j.vaccine.2019.09.029
OPRIESSNIG, TANJA; GAUGER, PHILLIP C.; GERBER, PRISCILLA F.; CASTRO, ALESSANDRA M. M. G.; SHEN, HUIGANG; MURPHY, LITA; DIGARD, PAUL; HALBUR, PATRICK G.; XIA, MING; JIANG, XI; TAN, MING. Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model. PLoS One, v. 13, p. e0191739, 2018. https://doi.org/10.1371/journal.pone.0191739

Curriculum Vitae

Anuska obtained her bachelor’s degree in Biological Sciences (2007) from UNESP´s Bauru School of Sciences, São Paulo State University, Brazil. and completed her Ph.D. in the Department of Microbiology, Immunology and Parasitology at Paulista Medical School, Federal University of São Paulo in 2013. She concluded postdoctoral fellow at Health Science Institute, Paulista University, Brazil (2013-2017) and at Institute of Sciences of Physical Activity and Health, Cruzeiro do Sul University, Brazil collaborating with Physiopathology Laboratory at Butantan Institute (2019-2021). In 2015, she described the regulatory role of B-1 lymphocytes in the diabetes experimental model and the ability of these cells to produce insulin. Currently, she studies cellular therapy using metabolic reprogramming of insulin-producing B-1 cells in vitro for their therapeutic use in Type 1 Diabetes. Her research focuses on B-1 cells' regulatory role in the diabetes model and their interactions with effector and regulatory T lymphocytes in the context of autoimmunity and metabolic diseases. She also contributes to several studies focusing on host-parasite relationship, Immune response in infections and immune response in tumoral models.

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Research Lines and Groups

• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações Terapêuticas
• Biologia da diferenciação e transformação celulares: modulação por fatores endógenos e exógenos
• Clininfec - Clínica e Doenças Infecciosas Veterinárias

Disciplines

• Da cultura de Células à Terapia Celular: Fundamentos e Avanços

Highlighted publications

Alvares-Saraiva AM et al. 2015. B-1 cells produce insulin and abrogate experimental streptozotocin-induced diabetes. Eur J Immunol, 45:1452-1461. DOI: https://doi.org/10.1002/eji.201445409

Da Costa LFV et al. 2016. B-1 cell decreases susceptibility to encephalitozoonosis in mice. Immunobiology, 222:218-227. DOI: https://doi.org/10.1016/j.imbio.2016.09.018

Francisco Neto A et al. 2017. Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice. PLoS One, 12:e0186954. DOI: https://doi.org/10.1371/journal.pone.0186954

Langanke dos Santos D et al. 2018. B-1 cells upregulate CD8 T lymphocytes and increase proinflammatory cytokines serum levels in oral encephalitozoonosis. Microbes infect, 20:196-204. DOI: https://doi.org/10.1016/j.micinf.2017.11.004

Pereira A et al. 2019. B-1 cell-mediated modulation of M1 macrophage profile can ameliorate microbicidal functions and disrupt the evasion mechanisms of Encephalitozoon cuniculi. PLoS Negl Trop Dis, 13:e0007674. DOI: https://doi.org/10.1371/journal.pntd.0007674

Curriculum Vitae

Veterinary physician from the Federal University of Pelotas (1985), M.Sc in Veterinary Medicine from the Federal University of Pelotas (1989), Specialist in Physiological Sciences from the University of Rio Grande (1993), Ph.D. in Experimental and Comparative Pathology from the University of São Paulo (1997) and postdoctoral researcher from the Universidade Paulista (2014). He has experience in morphology, focusing on neurobiology, acting on the following topics: glial cells, demyelination and remyelination, chemobrain (or post-chemotherapy cognitive dysfunction), neurodegenerative diseases, infectious and parasitic diseases related to the nervous system. Participates in the CNPq research groups of Experimental and Environmental Neuropsychopharmacology and Biological, Pharmacological and Toxicological Activities of Natural Products, both at UNIP. He is also a CNPq Productivity Fellow Teacher (level 1D).

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Research Lines and Groups

• Neuropsicofarmacologia Experimental e Ambiental
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Métodos de Investigação em Neuropatologia

Highlighted publications

Cardoso CV et al. 2020. Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration. Behav Brain Res, 378:112233. DOI: https://doi.org/10.1016/j.bbr.2019.112233

Molina J et al. 2020. Reduced astrocytic expression of GFAP in the offspring of female rats that received hypercaloric diet. Nutr Neurosci, 23:411-421. DOI: https://doi.org/10.1080/1028415X.2018.1512783

Ogassawara TB et al. 2018. Food deprivation in F0 generation and hypercaloric diet in F1 generation reduce F2 generation astrogliosis in several brain areas after immune challenge. Int J Dev Neurosci, 64:29-37. DOI: https://doi.org/10.1016/j.ijdevneu.2017.06.003

Nascimento BPP et al. 2018. Induction of type 2 iodothyronine deiodinase after status epilepticus modifies hippocampal gene expression in male mice. Endocrinology, 159: 3090-3104. DOI: https://doi.org/10.1210/en.2018-00146

Martins-Júnior JL et al., 2016. Propentofylline treatment on open field behavior in rats with focal ethidium bromide-induced demyelination in the ventral surface of the brainstem. Life Sci, 148:132-138. DOI: https://doi.org/10.1016/j.lfs.2016.02.028

Curriculum Vitae

Undergraduate as a Medical technologist at Universidad del Valle - Colombia (1994), Master in Science Applied to Pediatrics (2003), Ph.D. in Science at the Postgraduate Program in Microbiology and Immunology (2008) of the Federal University from São Paulo – Brazil (UNIFESP) and Post-doctor in tumor immunology (2011) by UNIFESP. Currently, she works as a full professor at the Graduate Program in Environmental and Experimental Pathology, being in charge of the Molecular and Cell Biology Laboratory of the Research Center at Universidade Paulista and working as a collaborating researcher in the Discipline of Immunology at UNIFESP. Her line of research encompasses the study of interactions between tumor cells and immune system components and their role in tumor formation and progression, besides the evaluation of the mechanisms of action of conventional and alternative anti-tumor drugs. She works in the areas of immunology, cell and molecular biology, transplants and microbiology, in the following topics: tumor immunology, tumor microenvironment, alternative therapies, extracellular vesicles, metabolism, immune response in infectious diseases caused by yeasts and parasites.  

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Research Lines and Groups

• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas
• Biologia da diferenciação e transformação celulares: modulação por fatores endógenos e exógenos
• Clininfec - Clínica e Doenças Infecciosas Veterinárias

Disciplines

• Técnicas biológicas em pesquisa
• Imunorregulação
• Seminários de Projetos
• Seminários da Semana Científica

Highlighted publications

Pérez EC et al. 2008. B-1 lymphocytes increase metastatic behavior of melanoma cells through the extracellular signal-regulated kinase pathway. Cancer Sci, 99(5):920-928. DOI: https://doi.org/10.1111/j.1349-7006.2008.00776.x

Staquicini FI et al. 2008. A subset of host B lymphocytes controls melanoma metastasis through a melanoma cell adhesion molecule/MUC18-dependent interaction: evidence from mice and humans. Cancer Res, 15;68(20):8419-8428. DOI: https://doi.org/10.1158/0008-5472.CAN-08-1242

Perez EC et al. 2017. The axis IL-10/claudin-10 is implicated in the modulation of aggressiveness of melanoma cells by B-1 lymphocytes. PLoS One, 12(11):e0187333. DOI: https://doi.org/10.1371/journal.pone.0187333

Almeida EB et al. 2019. A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment. Int J Mol Sci, 20(15):3765. DOI: https://doi.org/10.3390/ijms20153765

Colhado Rodrigues BL et al. 2020. The Controversial Role of Autophagy in Tumor Development: A Systematic Review. Immunol Invest, 49(4):386-396. DOI: https://doi.org/10.1080/08820139.2019.1682600

Curriculum Vitae

Giovani Peres é professor nas áreas de Ciências da Saúde e entusiasta da Educação. É Bacharel em Ciências Biológicas - Modalidade Médica pela Universidade Federal de São Paulo (2009), Mestre (2012) e Doutor em Ciências (2016) pelo programa de pós-graduação em Biologia Molecular da mesma Universidade. Também é Especialista em Administração de Empresas pela Fundação Getúlio Vargas (2014). Atualmente é Professor Titular da Universidade Paulista (UNIP), no Programa de Pós-Graduação em Patologia Ambiental e Experimental (Medicina Veterinária) e do curso de Biomedicina. Possui experiência em: a) pesquisa acadêmica na área de Bioquímica e Biologia Molecular, com ênfase em Glicoconjugados; b) ensino, lecionando do Pré-Vestibular à Pós-Graduação, atuando também em cargos de Coordenação; c) gestão colaborativa e administração de empresas.

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Research Lines and Groups

• Clininfec - Clínica e Doenças Infecciosas Veterinárias
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Estatística Aplicada à Pesquisa I
• Estatística Aplicada à Pesquisa II

Highlighted publications

Peres, GB et al. 2017. Impact of high glucose and AGEs on cultured kidney-derived cells. Effects on cell viability, lysosomal enzymes and effectors of cell signaling pathways. Biochimie, 135:137-148. DOI: http://dx.doi.org/10.1016/j.biochi.2017.02.004

De Santana, FR et al. 2017. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro. Cytokine, 92:33-47. DOI: http://dx.doi.org/10.1016/j.cyto.2017.01.004

Siqueira, SA et al 2017. Interface between breast cancer cells and the tumor microenvironment using platelet-rich plasma to promote tumor angiogenesis - influence of platelets and fibrin bundles on the behavior of breast tumor cells. Oncotarget, 8:16851-16874. DOI: http://dx.doi.org/10.18632/oncotarget.15170

Toricelli, M et al. 2013. Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Mol Cancer, 12:22. DOI: http://dx.doi.org/10.1186/1476-4598-12-22

Peres, GB et al. 2012. Lysosomal enzymes are decreased in the kidney of diabetic rats. Biochim Biophys Acta, 1832:85-95. DOI: http://dx.doi.org/10.1016/j.bbadis.2012.09.011

Curriculum Vitae

Veterinary Doctor from the University of São Paulo (1988), Residency in Veterinary Anatomic Pathology from the University of São Paulo (1991), Master (1993) and Doctor (1999) in Experimental and Comparative Pathology from the University of São Paulo, Specialist in Veterinary Pathology at ABPV. He is currently full professor at the Paulista University of São Paulo. He is advisor (master’s and doctoral level) at the Postgraduate Program in Environmental and Experimental Pathology at the Paulista University of São Paulo. Coordinates the research group "Biology of cell differentiation and transformation: modulation by endogenous and exogenous factors" - UNIP. He has experience in animal and comparative pathology, with an emphasis on diagnostic, prognostic and predictive markers in animal neoplasms; experimental and comparative oncology; veterinary surgical pathology; pathology of lymphohematopoietic organs.

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Research Lines and Groups

• Biologia da diferenciação e transformação celulares: modulação por fatores endógenos e exógenos
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Tópicos em Biologia Tumoral

Highlighted publications

Yasumaru CC et al. 2021. Intratumoral T-Lymphocyte Subsets in Canine Oral Melanoma and Their Association With Clinical and Histopathological Parameters. Vet Pathol, 25:300985821999321. DOI: https://doi.org/10.1177/0300985821999321

Nishiya AT et al. 2020. Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas. Toxins, 12(3):157. DOI: https://doi.org/10.3390/toxins12030157

Daniel J et al. 2019. Intratumoral collagen index predicts mortality and survival in canine cutaneous mast cell tumours. Vet Dermatol, 30(2):162-e48. DOI: https://doi.org/10.1111/vde.12726

Barra CN et al. 2018. Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours. Vet Comp Oncol, 16(1):E38-E44. DOI: https://doi.org/10.1111/vco.12330

Joselevitch JA et al. 2018. Nanog Expression and Proliferation Indices in Canine Cutaneous Mast Cell Tumors. Vet Pathol, 55(6):849-852. DOI: https://doi.org/10.1177/0300985818789470

Curriculum Vitae

Veterinary Doctor (USP, 1987), Master (1990) and Doctor (1995) in Experimental and Comparative Pathology from the University of São Paulo (USP), with a Doctorate in Sandwich at ENVL - France (1992-1993) and Post-Doctorate in Environmental Pathology and Experimental by UNIP (2015). Research Productivity Scholarship by CNPq level 2 between 2011-2014 and 2018-2021. President (2002-2008) and Vice President (2008-2014) of GIRI (Groupe International de Recherche sur l'Infinitésimal). Deputy-Editor of the journal "Homeopathy – The Journal of the Faculty of Homeopathy – London." Member of the Editorial Board of the International Journal of High Dilution Research (IJHDR) and the "Water – A multidisciplinary research journal." Member of the Homeopathy Research Institute ( HRI, UK) since 2013 and the International Panel on Water Structure (IPWS) since 2020. Coordinator of the project "Map of Evidence in Homeopathy" (2021), organized by CABSIN - Brazilian Academic Consortium of Integrative Health, with Fiocruz–RJ's support.

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Research Lines and Groups

• Neuropsicofarmacologia Experimental e Ambiental
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Susceptibilidade e complexidade na abordagem da saúde única
• Tópicos Especiais Aplicados à Educação

Highlighted publications

Bonamin LV et al. 2019. Transdisciplinarity and Translationality in High Dilution Research. 1. ed. Cambridge: Cambridge Scholars Publishing, 277pp. Link: https://www.cambridgescholars.com/product/978-1-5275-3252-6

Endler, PC et al. 2010. Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study. Homeopathy, 99:25-36. DOI: https://doi.org/10.1016/j.homp.2009.11.008

Santana FR et al. 2017. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro. Cytokine, 92: 33-47. DOI: https://doi.org/10.1016/j.cyto.2017.01.004

Aparicio AC et al. 2020. Interaction between solvatochromic dyes and water sampled from a natural source treated with high dilutions of phosphorus. Homeopathy, 109:126-132. DOI: https://doi.org/10.1055/s-0039-3400255

Bonamin LV. 2020. Characterization of Antimonium crudum Activity Using Solvatochromic Dyes. Homeopathy, 109:79-86. DOI: https://doi.org/10.1055/s-0039-1697000

Curriculum Vitae

Degree in Biological Sciences from the University of São Paulo, Master's and Doctorate in Physiology, concentration area Pharmacology from the Institute of Biomedical Sciences of the University of São Paulo and Post-doctorate at the Department of Pharmacology at the Institute of Biomedical Sciences-USP and the Faculty of Veterinary Medicine and Animal Science-USP. Senior Visiting Professor (CAPES) at the Federal University of ABC. Linked to the graduates Program in Environmental and Experimental Pathology of Veterinary Medicine,Universidade Paulista. Has experience in Pharmacology, Toxicology, and Neurosciences. The most important line of research is involved with Developmental Toxicology and Neurosciences and Behavior. Studies the changes promoted in the perinatal period by immune system modulators, drugs, heavy metals, pesticides, and endocrine disruptors to investigate the behavioral, endocrine, epigenetic, molecular aspects, and the development of animal models of mental disorders. Since 2016, has been part of the Zebrafish Platform, which aims to disseminate, study and establish models in this fish for studies in the most varied areas of science. Is the editor of the book Pharmacology Applied to Veterinary Medicine and has several chapters in books on Pharmacology and Veterinary Toxicology and a book on Animal Behavior. Leader-coordinator of the Research-CNPq Experimental and Environmental Neuropsychopharmacology group.

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Research Lines and Groups

• Neuropsicofarmacologia Experimental e Ambiental
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Toxicologia do Desenvolvimento e da Reprodução
• Bioética e Metodologia da Pesquisa Científica

Highlighted publications

Bernardi et al. 2021. Overweight induced by hypernutrition in juvenile rats dysregulates the central monoamines in the adult age. Psychol Neurosci, 14:34-48. DOI: https://doi.org/10.1037/pne0000204

Mendes-Lima et al. 2020. Prenatal LPS induces sickness behaviour and decreases maternal and predatory behaviours after an LPS challenge. Int J Neurosci, 130(8):804-816. DOI: https://doi.org/10.1080/00207454.2019.1706505

Reis-Silva et al. 2019. Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test. Eur J Neurosci, 50(6):2942-2954. DOI: https://doi.org/10.1111/ejn.14409

Cordeiro et al. 2018. Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats. Res Vet Sci, 117:178-186. DOI: https://doi.org/10.1016/j.rvsc.2017.12.013

Lima et al. 2017.Acute lipopolysaccharide switches the selection of maternal behavior to predatory behavior in female rats. Neuroimmunomodulation, 24(1):1-10. DOI: https://doi.org/10.1159/000469711

Curriculum Vitae

Graduated in Biology from the University of the Sacred Heart (2005) and Ph.D. by the Functional and Molecular Biology program at Unicamp (2011). Performed Post-doctoral internships at the Faculty of Dentistry of Piracicaba/UNICAMP (2011), at the Federal University of Santa Catarina/UFSC (2013) and at the Biosciences Institute of Botucatu/IBB (2016) with sandwich periods at the Electronic Microscopy Center of UNC, Córdoba/AR; at the Laboratory for Gastroenterology and Hepatology, ERASMUS Medical Center, Rotterdam/NL and at the Centro de Investigaciones Biomédicas y Regulación del Genome at Universidad Andres Bello, Santiago/CL. Leader of the research group Epigenetic mechanisms applied to the transcriptional control of CNPq, scientific consultant for international journals and member of the Internal Biosafety Research Commission at Universidade Paulista / UNIP (CIBio). Have experience in Biochemistry and Molecular Biology, with an emphasis on cell signaling and epigenetic regulation mechanisms. His researches is mainly focused on the study of epigenetic mechanisms applied to transcriptional control. Working mainly in the fields of Neuroepigenetics applied to aging, differentiation of mesenchymal cells and Maternal and Fetal Epigenetics.

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Research Lines and Groups

• Neuropsicofarmacologia Experimental e Ambiental
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Epigenética Básica I
• Epigenética Básica II

Highlighted publications

Assis RIF et al. 2021. Non-coding RNAs repressive role in post-transcriptional processing of RUNX2 during the acquisition of the osteogenic phenotype of periodontal ligament mesenchymal stem cells. Dev Biol. Feb, 470:37-48. DOI: https://doi.org/10.1016/j.ydbio.2020.10.012

da Silva RA et al. 2019. HOXA cluster gene expression during osteoblast differentiation involves epigenetic control. Bone, 125:74-86. DOI: https://doi.org/10.1016/j.bone.2019.04.026

da Silva RA et al. 2019. Osteogenic gene markers are epigenetically reprogrammed during contractile-to-calcifying vascular smooth muscle cell phenotype transition. Cell Signal, 66:109458. DOI: https://doi.org/10.1016/j.cellsig.2019.109458

da Silva RA et al.2019. Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation. Mol Neurobiol, 56:1539-1557. DOI: https://doi.org/10.1007/s12035-018-1175-9

da Silva RA et al. 2019. Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells. J Cell Physiol, 234:6382-6396. DOI: https://doi.org/10.1002/jcp.27374

Curriculum Vitae

Bachelor's and Licentiate degrees in Biological Sciences. Master (MSc) and Ph.D. in Sciences (FMVZ-USP). Postdoctoral research fellow; FAPESP grants. Currently Full Professor and Scientist Researcher of the Stricto Sensu Program in Environmental and Experimental Pathology, Paulista University (score CAPES 5). Leader of the Psychoneuroimmunology Laboratory and of a CNPq Research Group: Experimental and Environmental Neuropsychopharmacology. Advisor, Scientific Consultant, and Reviewer of an ethics committee on the use of animals and of international scientific journals. Medical writer of 55+ scientific papers published in international scientific journals, in addition to book chapters and didactic/instructional books. His Ph.D. thesis has won the 'Capes Thesis Award' (best Thesis), competing with a thesis from all over the country. Research expertise in scientific/therapeutical areas of Psychoneuroimmunology, Neuropsychopharmacology, Neuroscience, Animal Behavior, Experimental Models, Mental Health, Neuropsychiatric Disorders, Perinatal Studies, Microbiology, Pharmacology, Toxicology, and Molecular Biology.

More information

• Currículo Lattes
• Google Scholar
• ORCID
• ResearchGate
• LinkedIn

Research Lines and Groups

• Neuropsicofarmacologia Experimental e Ambiental
• Patologia Integrada e Translacional
• Ecotoxicologia e Inovações terapêuticas

Disciplines

• Modelos Experimentais em Comportamento de Animais de Laboratório
• Tópicos Especiais Aplicados à Educação

Highlighted publications

Kirsten TB et al. 2020. Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats. Brain Behav Immun, 87:489-497. DOI: https://doi.org/10.1016/j.bbi.2020.01.019

Parisi DP et al. 2019. Therapeutical doses of ivermectin and its association with stress disrupt motor and social behaviors of juvenile rats and serotonergic and dopaminergic systems. Res Vet Sci, 124: 149-157. DOI: https://doi.org/10.1016/j.rvsc.2019.03.009

Leme E et al. 2018. Billings reservoir water used for human consumption presents microbiological contaminants and induces both behavior impairments and astrogliosis in zebrafish. Ecotoxicol Environ Saf, 161:364-373. DOI: https://doi.org/10.1016/j.ecoenv.2018.06.009

Kirsten TB et al. 2018. Pioglitazone abolishes autistic-like behaviors via the IL-6 pathway. PLoS One, 13:e0197060. DOI: https://doi.org/10.1371/journal.pone.0197060

Kirsten TB et al. 2015. Lipopolysaccharide Exposure Induces Maternal Hypozincemia, and Prenatal Zinc Treatment Prevents Autistic-Like Behaviors and Disturbances in the Striatal Dopaminergic and mTOR Systems of Offspring. Plos One, 10:e0134565. DOI: https://doi.org/10.1371/journal.pone.0134565