Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

A Patogenia da Susceptibilidade

Ementa:A relação doente, doença e ambiente é compreendida sob o foco dos mecanismos de susceptibilidade do paciente, levando em conta os aspectos mais variados, tais como: senso de perigo, autopoiese, sensoreamento de quórum, hereditariedade, epigenética e biossemiótica. Em relação a esse último aspecto, abre-se a possibilidade de remediação desses mecanismos pela homeopatia. O processo de aprendizado deste assunto requer a revisitação do modelo clássico de imunidade (self-non-self), bem como do determinismo das vias metabólicas e de regulação intra-celular. Dessa forma, as doenças infecciosas deixam de ser vistas como simples fatores resultantes de imunodepressão e fatores de virulência e passam a ser caracterizadas como desbalanços de uma complexa rede formada não apenas pelos sistemas imune, nervoso e endócrino, mas também pelo ambiente e os demais organismos nele presentes, os quais interagem continuamente. Fatores moduladores como estresse, medicamentos, poluição, sazonalidade, radiação, gravidade, etc. seriam, portanto, agentes perturbadores desta rede. Aulas formais, estudo-dirigidos, seminários e palestras internacionais on-line estão previstos para essa disciplina.

Bibliografia:

APARICIO ACC, OLIVEIRA LHS, SILVA JS, COELHO CP, PINHEIRO SR, SOUZA MF, SUFFREDINI IB, CARTWRIGHT ST, BONAMIN LV. Interaction between solvatochromic dyes and water sampled from a natural source treated with high dilutions of phosphorus. Homeopathy (2019). doi: 10.1055/s-0039-3400255. [In press].

BISHAYEE K, SIKDAR S, KHUDA-BUKSHS AR. Evidence of an Epigenetic Modification in Cell-cycle Arrest Caused by the Use of Ultra-highly-diluted Gonolobus Condurango Extract. J Pharmacopuncture. 2013; 16(4):7-13. doi: 10.3831/KPI.2013.16.024.

BLALOCK JE, SMITH EM. Conceptual development of the immune system as a sixth sense. Brain Behav Immun. 2007; 21(1):23-33.

BONAMIN LV, PEDRO RRP, MOTA HMG, AGUIAR MSC, PINTO SAG, DE SOUZA J, DE OLIVEIRA LHS, APARICIO AC, PERES GB, SUFFREDINI I, DUTRA-CORREA M, CARTWRIGHT SJ. Characterization of Antimonium crudum Activity Using Solvatochromic Dyes. Homeopathy (2019). doi: 10.1055/s-0039-1697000. [Epub ahead of print].

BONAMIN, L.V.; WAISSE, S. Transdisciplinarity and Translationality in High Dilution Research. Cambridge, Cambridge Scholars, 2019. 277pp.

BONAMIN, LV et al. RATS BORN TO MOTHERS TREATED WITH DEXAMETHASONE 15 cH PRESENT CHANGES IN MODULATION OF INFLAMMATORY PROCESS. e-CAM, 2012. Article: 710923; 10 pages; Doi: 10.11 55/2012/7 10923

BONAMIN, L.V. (Ed). Signal and Images: contributions and contradictions about high dilution research. Dordrecht: Springer, 2008. 222pp.

BOOIJ, L.; WANG, D.; LEVESQUE, M.L.; TREMBLAY, R.E.; SZYF, M. Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress - diathesis model of depression. Phi Trans R Soc B 368: 20120251. http://dx.doi.org/10.1098/rstb.2012.0251

BROD S, RATTAZZI L, PIRAS G, D'ACQUISTO F.  'As above, so below' examining the interplay between emotion and the immune system. Immunology. 2014 Nov;143(3):311-8. doi: 10.1111/imm.12341. Review.

COELHO CP, MOTTA PD, PETRILLO M, DE OLIVEIRA IOVINE R, DALBONI LC, SANTANA FR, CORREIA MS, CASARIN RC, CARVALHO VM, BONAMIN LV. Homeopathic medicine Cantharis modulates uropathogenic E. coli (UPEC)-induced cystitis in susceptible mice. Cytokine. 2017 Apr;92:103-109. doi: 10.1016/j.cyto.2017.01.014.

DE NINNO A; PREGNOLATO M. Electromagnetic homeostasis and the role of
low-amplitude electromagnetic fields on life organization. Electromagnetic Biology and Medicine 2016; DOI: 10.1080/15368378.2016.1194293.

DEL GIUDICE E; ELIA V; TEDESCHI A. The role of water in the living organisms. Neural Network World, 2009, 4(09): 355-360.

FARIA, M. Signal transduction and cell fate. In: BARBIERI, M. The codes of Life. Dordrecht: Springer, 2008.

HAROON F, HÄNDEL U, ANGENSTEIN F, GOLDSCHMIDT J, KREUTZMANN P, LISON H, FISCHER KD, SCHEICH H, WETZEL W, SCHLÜTER D, BUDINGER E. Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS One. 2012;7(4):e35516. doi: 10.1371/journal.pone.0035516.

JACOB, E.B. et al. Bacterial linguistic communication and social intelligence. Trends in microbiology, v.12, n.8, p.366-372, 2004.

JOAQUIM AO, COELHO CP, DIAS MOTTA P, FELICIO LF, BONDAN EF, TEODOROV E, MARTINS MFM, KIRSTEN TB, BONAMIN LV AND BERNARDI MM. Maternal food restriction in rats of the F0 generation increases retroperitoneal fat, the number and size of adipocytes and induces periventricular astrogliosis in female F1 and male F2 generations. Reproduction, Fertility and Development. http://dx.doi.org/10.1071/RD15309

KOKORNACZYK MO, BAUMGARTNER S, BETTI L. Polycrystalline structures formed in evaporating droplets as a parameter to test the action of Zincum metallicum 30c in a wheat seed model. Homeopathy, 2016, v. 105, in press.

KOSTANTINOVA, I.V.; RYKOVA, M.P.; LESNYAK, A.T.; ANTROPOVA, E.A. Immune changes during long-duration missions. Journal of Leukocyte Biology, v.54, p. 189-201, 1993.

MAROTTI l; BETTI L; BREGOLA V; BOSI S; TREBBI G; BORGHINI G; NANI D; DINELLI G. Transcriptome Profiling of Wheat Seedlings following Treatment with Ultrahigh Diluted Arsenic Trioxide. Evidence-Based Complementary and Alternative Medicine (2014) ID 851263. DOI: 10.1155/2014/851263.

MARZOTTO M, BONAFINI C, OLIOSO D, BARUZZI A, BETTINETTI L, DI LEVA F, GALBIATI E, BELLAVITE P. Arnica montana Stimulates Extracellular Matrix Gene Expression in a Macrophage Cell Line Differentiated to Wound-Healing Phenotype. PLoS One. 2016 Nov 10;11(11):e0166340. doi: 10.1371/journal.pone.0166340.

MATURANA H. A ontogenia da realidade. Belo Horizonte, Ed UFMG, 2004

MATZINGER, P. An innate sense of danger. Seminars in Immunology, v.10, p. 399-425, 1998

PASSETI TA; BISSOLI LR; MACEDO AP; LIBAME BR; DNIZ S; WAISSE S. Action of antibiotic oxacillin on in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) previously treated with homeopathic medicines. Homeopathy (2017), 106, 27-31.

SAVINO, W.; AYRES-MARTINS, S.; NEVES DOS SANTOS, S.; SMANIOTTO, S.; OCAMPO, J.S.P.; MENDES DA CRUZ, D.A.; TERRA GRANADO, E.; KUSMENOK, O.; VILLA VERDE, D.M.S. Thymocyte migration: an affair of multiple cellular interactions? Braz. J. Med. Biol. Res., v.26, p.1015-1025, 2003.

SANTANA, F.R. et al. Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines: Atimonium crudum 30cH. Homeopathy v 103, p.264-274, 2014.

SANTANA FR, DALBONI LC, NASCIMENTO KF, KONNO FT, ALVARES-SARAIVA AM, CORREIA MS, BOMFIM MD, CASARIN RC, PEREZ EC, LALLO MA, PERES GB, LAURENTI MD, BENITES NR, BUCHI DF, BONAMIN LV.  High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro. Cytokine. 2017 Jan 13;92:33-47. doi: 10.1016/j.cyto.2017.01.004.

VARELA FJ; COUTINHO A. Second generation immune networks. Immunology Today, 12, p.159-166, 1991.

VAZ, N.M.; PORDEUS, V. Visiting Immunology. Arquivos Brasileiros de Cardiologia. v.85. on-line. 2005.

WAISSE S, BONAMIN LV. Explanatory models for homeopathy: from the vital force to the current paradigm. Homeopathy. 2016 Aug;105(3):280-5. doi: 10.1016/j.homp.2016.02.003.