Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Tópicos em biologia tumoral

Ementa

Abordagem de elementos relevantes em oncologia, dentro de um enfoque celular e molecular, relacionando características biológicas norteadoras da condição com a elaboração de trajetos para o diagnóstico e terapêutica desses processos. Conceito, classificação, diferenças entre neoplasias benignas e malignas. Características biológicas centrais, circuitaria proliferativa e metabolismo tumoral. Princípios diagnósticos: citopatologia, histopatologia e imuno-histoquímica. Microambiente tumoral e dormência. Metastatização. Estratégias terapêuticas.

Bibliografia

BOROVSKI, T.; MELO, F.S.; VERMEULEN, L.; MEDEMA, J.P. Cancer stem cell niche: the place to be. Cancer Research, v. 7, p. 634-639, 2011.
EVANS, C. E.; BRANCO-PRICE, C.; JOHNSON, R. S. HIF-mediated endothelial response during cancer progression. International Journal of Hematology, v. 95, n. 5, p. 471-477, 2012.
FOUAD, Y.A.; AANEI, C. Revisiting the hallmarks of cancer. Am J Cancer Res, v.7, p.1016-1036, 2017.
GEISSMANN, F.; MASS, E. A stratified myeloid system, the challenge of understanding macrophage diversity. Semin Immunol. v. 27, n.6, p.353-6, 2015.
HANAHAN, D.; WEINBERG, R.A. The hallmarks of cancer. Cell, v. 100, n. 1, p. 57-70, 2000.
HANAHAN, D.; WEINBERG, R.A. The hallmarks of cancer: the next generation. Cell, v. 144, n. 5, p. 646-674, 2011.
JIE, L.; CHEN, J.L.; QIN, Z. Multifaceted tumor stromal fibroblasts. Cancer Microenvironment, v. 5, n.3, p.187-193, 2012.
MILLS, C.D. M1 and M2 macrophages: oracles of health and disease. Critical Reviews in Immunology, v. 32, n.6, p. 463-488, 2012.
PIETRAS, K.; OSTMAN, A. Hallmarks of cancer: interactions with the tumor stroma. Experimental Cell Research, v. 316, p. 1324-1331, 2010.
RAMOS-VARA, J.A. Technical aspects of immunohistochemistry. Veterinary pathology, v. 42, n. 4, p. 405-426, 2005.
ROSENBLOOM, D.I.S. et al. Evolutionary scalpels for dissecting tumor ecosystems. Biochimica et Biophysica Acta Rev Cancer, v.1867, n.3, p. 69-83, 2017.
RUEGG, C. Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions. Journal of Leukocyte Biology, v. 80, n. 4, p. 682-4, 2006.
SAMPIERI, K.; FODDE, R. Cancer stem cells and metastasis. Seminars in Cancer Biology, v. 22, p. 187-193, 2012.
SCHEEL, C.; ONDER, T.; KAMOUB, A.; WEINBERG, R.A. Adaptation versus selection: the origins of metastatic behavior. Cancer Research, v. 87, p. 11476- 11480, 2007.
SHIBUE, T.; WEINBERG, R.A. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Seminars in Cancer Biology, v. 21, p. 99-106, 2011.
SLEEMAN, J.P.; CHRISTOFORI, G.; FODDE, R.; COLLARD, J.G.; BERX, G.; DECRAENE, C.; RUEGG, C. Concepts of metastasis in flux: the stromal progression model. Seminars in Cancer Biology, v. 22, p. 174-186, 2012.
TALMADEE, J.E.; DONKOR, M.; SCHOLAR, E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Reviews, v. 26, p. 373-400, 2007.
TALMADGE, J.E. Clonal selection of metastasis within the life history of a tumor. Cancer Research, v. 67, p. 11471-11475, 2007.
MEDZHITOV, R. Inflammation 2010: new adventures of an old flame. Cell, v. 140, p. 771-776, 2010.
URABE, F. et al. The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment. Clin Trans. Med., 6: 45, 2017.
WEINBERG, R.A. A biologia do câncer. Porto Alegre: Artmed, 2008.
YI, S.; HAO, Y.; NAN, K.; FAN, T. Cancer stem cell niche: a target for novel cancer therapeutics. Cancer Treatments Reviews, v. 39, p. 290-296, 2013.