Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Tópicos em Biologia Tumoral: Biologia da Disseminação

Ementa

Elementos relevantes do processo de disseminação tumoral. Teorias de crescimento tumoral e vias de disseminação. CSCs, dormência tumoral e nichos pré-metastáticos. Neurotransmissores, quimiocinas e disseminação tumoral. Microambiente tumoral; estroma e invasão. Marcadores prognósticos em oncologia. Inflamação, imunidade e imunoterapia no câncer: aspectos críticos.

Bibliografia

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FOKAS, E.; ENGENHART-CABILLIC, R.; DANIILIDIS, K.; ROSE, F.; AN, H.-X. Metastasis: the seed and soil theory gains identity. Cancer Metastasis Reviews, v. 26, n. 3-4, p. 705-715, Dec. 2007.
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SLEEMAN, J. P.; CHRISTOFORI, G.; FODDE, R.; COLLARD, J. G.; BERX, G.; DECRAENE, C.; RÜEGG, C. Concepts of metastasis in flux: the stromal progression model. Seminars in Cancer Biology, v. 22, n. 3, p. 174-186, June 2012.
TALMADGE, J. E. Clonal selection of metastasis within the life history of a tumor. Cancer Research, v. 67, n. 24, p. 11471-11475, Dec. 2007.
TALMADGE, J. E.; DONKOR, M.; SCHOLAR, E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Reviews, v. 26, n. 3-4, p. 373-400, Dec. 2007.
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WITZ, I. P. Yin-yang activities and vicious cycles in the tumor microenvironment. Cancer Research, v. 68, n. 1, p. 9-13, Jan. 2008.
YI, S.; HAO, Y.; NAN, K.; FAN, T. Cancer stem cell niche: a target for novel cancer therapeutics. Cancer Treatments Reviews, v. 39, n. 3, p. 290-296, May 2013.
ZUMSTEG, A.; CHRISTOFORI, G. Corrupt policemen: inflammatory cells promote tumor angiogenesis. Current Opinion in Oncology, v. 21, n. 1, p. 60-70, Jan. 2009