Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Tópicos em Biologia Tumoral: Biologia da Disseminação

Ementa

O câncer apresenta-se como importante problema de saúde pública, exibindo elevada morbidade e mortalidade em todo o mundo. A principal limitação à resolução dessa condição é o seu potencial de disseminação. Neste contexto a disciplina visa abordar elementos relevantes do processo de disseminação  tumoral, dentro de um enfoque celular e molecular, destacando-se:
Teorias de crescimento tumoral e vias de disseminação
CSCs, dormência tumoral e nichos pré-metastáticos;
Neurotransmissores, quimiocinas e disseminação tumoral;
Microambiente tumoral; estroma e invasão ;
Marcadores prognósticos em oncologia;
Inflamação, imunidade e imunoterapia no câncer: aspectos críticos.

Bibliografia

Aspectos gerais:
WEINBERG, RA. A biologia do câncer, Porto Alegre, Artmed, 2008, 864p.
HANAHAN D, WEINBERG RA. The hallmarks of cancer, Cell, v. 100, p. 57-70, 2000.
HANAHAN D, WEINBERG RA. The hallmarks of cancer. The new generation, Cell, v. 100: 57-70, 2011.
Metástase
FREIREICH, EJ.; KURZROCK, R.; ESTROV, Z. Metastasis- an alternative hypothesis. Cancer, v. 103, p. 1537-1539, 2005.
GUARINO M. Epithelial-mesenchymal transition and tumour invasion, International Journal of Biochemistry Cell Biology, v. 39, p. 2153-60, 2007.
SCHEEL, C.; ONDER, T.; KAMOUB, A.; WEINBERG, RA. Adaptation versus selection: the origins of metastatic behavior. Cancer Research, v. 87, p. 11476-11480, 2007.
TALMADGE, JE. Clonal selection of metastasis within the life history of a tumor. Cancer Research, v. 67, p. 11471-11475, 2007.
FOKAS E, ENGENHART-CABILLIC R, DANIILIDIS K, ROSE F, AN HX. Metastasis:the seed and soil theory gains identity, Cancer Metastasis Reviews, v. 26, p. 705-715, 2007.
KLEIN, CA. The metastatic cascade. Science, v. 321, p. 1785-1787, 2008.
PSAILA, B.; LYDEN, D. The metastatic niche: adapting the foreign soil. Nature Cancer Reviews, v. 9, p. 285-293, 2009.
SHIBUE, T.; WEINBERG, RA. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Seminars in Cancer Biology, v. 21, p. 99-106, 2011.
SLEEMAN, JP.; CHRISTOFORI, G.; FODDE, R.; COLLARD, JG.; BERX, G.; DECRAENE, C.; RUEGG, C. Concepts of metastasis in flux: the stromal progression model,  Seminars in Cancer Biology , v. 22, p. 174-186, 2012.
Cancer stem cells
MALANCHI, I.; HUELSKEN, J. Cancer stem cells: never Wnt away from the niche. Current Opinion in Oncology, v. 21, p. 41-46, 2008.
BOROVSKI, T.; MELO, FS.; VERMEULEN, L.; MEDEMA, JP. Cancer stem cell niche: the place to be. Cancer Research, v. 7, p. 634-639, 2011.
SAMPIERI, K.; FODDE, R. Cancer stem cells and metastasis. Seminars in Cancer Biology, v. 22, p. 187-193, 2012.
YI, S; HAO, Y; NAN, K; FAN, T. Cancer stem cell niche: a target for novel cancer therapeutics. Cancer Treatments Reviews, v. 39, p. 290-296, 2013.
Microambiente tumoral
WITZ, IP. Ying-yang activities and vicious cycles in the tumor microenvironment. Cancer Research, v. 88, p. 9-13, 2008.
PIETRAS, K.; OSTMAN, A. Hallmarks of cancer: interactions with the tumor stroma. Experimental Cell Research, v. 316, p. 1324-1331, 2010.
UHR, JW.; PANTEL, K. Controversies in clinical cancer dormancy. Proceedings of the National Academy of Sciences, v. 108, p. 12396-1240, 2011.
REDDY, BY.; LIM, PK.; SILVERIO, K.; PATEL, AS.; WON, BW.; RAMESHWAR, P. The microenvironment effect in the progression, metastasis and dormancy of breast cancer: a model system within bone marrow. International Journal of Breast Cancer, 2012, 7pgs.
CHEN, JL.; QIN, Z. Multifaceted tumor stromal fibroblasts. Cancer Microenvironment, 2012, 7 pgs.
Inflamação e câncer
RUEGG C, Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions, Journal of Leukocyte Biology, v. 80, p.1-3, 2006.
LEWIS C, MURDOCH C. Macrophage responses to hypoxia-implications for tumor progression and
anti-cancer therapies, American Journal of Pathology, v. 167: 627-635, 2005.
CHEN JJW, LIN YC, YAO PL, YUAN A, CHEN HY, SHUN CT, TSAI MF, CHEN CH, YANG PC. Tumor-associated macrophages: the double-edged sword in cancer progression, Journal of Clinical Oncology, v. 23, p. 953-964, 2005.
TALMADEE JE, DONKOR M, SCHOLAR E. Inflammatory cell infiltration of tumors: Jekyll or Hyde, Cancer Metastasis Reviews, v. 26, p. 373-400,2007.
ZUMSTEG, A.; CHRISTOFORI, G. Corrupt policemen: inflammatory cells promote tumor angiogenesis. Current Opinion in Oncology, v. 21, p. 60-70, 2008.
WEGROWSKI Y, MAQUART FX. Chondroitin sulfate proteoglycans in tumor progression,
Advances in Pharmacology, v. 53, p.297-321, 2006.