Programa de Pós-Graduação Stricto Sensu em Patologia Ambiental e Experimental

Tópicos em Biologia Tumoral

Ementa

Estudo dos elementos relevantes da biologia tumoral, dentro de um enfoque celular e molecular, destacando-se aspectos relativos às células neoplásicas, ao microambiente tumoral e a resposta do hospedeiro, em associação aos principais métodos de investigação destes eventos. Os temas centrais são: circuitaria molecular no câncer: ciclo celular, proliferação e diferenciação celular; imuno-histoquímica: princípios e aplicações, recuperação antigênica e sistemas de amplificação; genética molecular do câncer: instabilidade cromossômica e mutações, oncogenes, genes supressores de tumores, eventos epigenéticos; estroma e invasão tumoral: vasculogênese tumoral (contexto molecular, padrões de organização, marcadores e quantificação), MEC e câncer, hipóxia e progressão tumoral; inflamação, macrófagos, células dendríticas, células natural-killer e câncer; câncer como doença sistêmica/metástase.

Bibliografia

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